When faced with the perplexing situation of a negative urine culture result, a pivotal question arises: should I continue the course of antibiotics I’ve been prescribed? It’s a conundrum that invites myriad considerations. On one hand, antibiotics are deemed essential for combating bacterial infections, yet if the culture indicates an absence of pathogens, what’s the rationale for their continued use? Could the persistence of these medications lead to unnecessary side effects or contribute to antibiotic resistance? Moreover, might there be underlying factors or alternative infections not captured by the standard urine culture? How do the nuances of individual health—such as age, existing comorbidities, or symptomatic severity—factor into this decision-making process? Is it prudent to consult with a healthcare professional for tailored guidance, or does the instinct to self-manage take precedence? Ultimately, the intersection of evidence-based medicine and personal circumstances presents a complex landscape for determining the right course of action.